Classical music, educational learning, and slow wave sleep: A targeted memory reactivation experiment

Memory stabilization with targeted reactivation during human slow-wave sleep.

It is believed that neural representations of recent experiences become reactivated during sleep, and that this process serves to stabilize associated memories in long-term memory. Here, we initiated this reactivation process for specific memories during slow-wave sleep. Participants studied 50 object-location associations with object-related sounds presented concurrently. For half of the assoc...

Targeted Memory Reactivation during Sleep Depends on Prior Learning.

STUDY OBJECTIVES When sounds associated with learning are presented again during slow-wave sleep, targeted memory reactivation (TMR) can produce improvements in subsequent location recall. Here we used TMR to investigate memory consolidation during an afternoon nap as a function of prior learning. PARTICIPANTS Twenty healthy individuals (8 male, 19-23 y old). MEASUREMENTS AND RESULTS Partic...

Cued memory reactivation during slow-wave sleep promotes explicit knowledge of a motor sequence.

Memories are gradually consolidated after initial encoding, and this can sometimes lead to a transition from implicit to explicit knowledge. The exact physiological processes underlying this reorganization remain unclear. Here, we used a serial reaction time task to determine whether targeted memory reactivation (TMR) of specific memory traces during slow-wave sleep promotes the emergence of ex...

Cued reactivation during slow-wave sleep induces connectivity changes related to memory stabilization

Closed-Loop Targeted Memory Reactivation during Sleep Improves Spatial Navigation

Sounds associated with newly learned information that are replayed during non-rapid eye movement (NREM) sleep can improve recall in simple tasks. The mechanism for this improvement is presumed to be reactivation of the newly learned memory during sleep when consolidation takes place. We have developed an EEG-based closed-loop system to precisely deliver sensory stimulation at the time of down-s...